| 刊名 | Plant Diseases and Pests |
| 作者 | Quan QUAN, Junhao LI, Xichun HUANG, Zhao NING, Hongye LI, Wenhui ZHAO, Chenghao JIN |
| 作者单位 | College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University |
| DOI | 10.19579/j.cnki.plant-d.p.2026.03-04.009 |
| 年份 | 2026 |
| 刊期 | 2 |
| 页码 | 38-42 |
| 关键词 | Dulcitol, Dianhydrogalactitol (DAG), Diacetyldianhydrogalactitol (DADAG), Pharmacological effect, Molecular mechanism |
| 摘要 | Through a comprehensive review of both domestic and international literature, the pharmacological effects and molecular mechanisms of dulcitol and its derivatives have been systematically summarized. The findings demonstrate that dianhydrogalactitol (DAG) and diacetyldianhydrogalactitol (DADAG) induce apoptosis in tumor cells, inhibit angiogenesis, and arrest the cell cycle via mitochondrial, death receptor, and endoplasmic reticulum stress pathways. Additionally, dulcitol mitigates intestinal inflammation and barrier damage by inhibiting the TLR4/MyD88/NF-κB signaling pathway, while also modulating intestinal microbiota and promoting defecation. Collectively, dulcitol and its derivatives exhibit multi-target pharmacological activities, indicating their promising potential in the prevention and treatment of cancer and intestinal disorders. |
