Pharmacological Effects of Piceatannol on Anti-tumor, Anti-inflammatory, Antiviral, and Liver Protection
| 刊名 |
Asian Agricultural Research |
| 作者 |
Junhao LI， Quan QUAN， Xichun HUANG， Zhao NING， Hongye LI， Wenhui ZHAO， Chenghao JIN |
| 作者单位 |
College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University |
| DOI |
10.19601/j.cnki.issn1943-9903.2026.06.004 |
| 年份 |
2026 |
| 刊期 |
6 |
| 页码 |
26-29，32 |
| 关键词 |
Piceatannol, Anti-tumor, Anti-inflammatory, Liver protection, Antiviral, Myocardial protection |
| 摘要 |
Piceatannol (PIC) is a natural stilbene polyphenol found in various plants, which has pharmacological effects such as anti-tumor, anti-inflammatory, antiviral, liver protection, myocardial protection, and eye tissue protection. PIC can inhibit the proliferation of liver cancer cells and induce apoptosis and autophagy by activating the ULK1/Atg13 signaling pathway. PIC can reduce HBV inflammation by downregulating the Notch pathway. Through antioxidant, anti-inflammatory, and anti abnormal autophagy, PIC can relieve vomiting toxin induced liver injury. By inhibiting the HMGB1/TLR4/NF-κB pathway, PIC can protect myocardium. By activating the SIRT1/FOXO3a/BNIP3 pathway, PIC can protect corneal epithelial cells from oxidative damage. PIC can directly inhibit rotavirus and conduct antiviral biosynthesis. PIC has high safety, multi-target regulation, and good development prospects, but its molecular mechanism and clinical efficacy still need to be further studied. |
