Pharmacological Effects of Nardosinone in Anti-Rheumatoid Arthritis, Anti-Tumor, Anti-Arrhythmia, and Myocardial Protection
| 刊名 |
Asian Agricultural Research |
| 作者 |
Huizhen PEI, Jiaru YE, Shuang REN, Linbo JIA, Wenhui ZHAO, Chenghao JIN |
| 作者单位 |
College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing 163319, China |
| DOI |
10.19601/j.cnki.issn1943-9903.2026.05.010 |
| 年份 |
2026 |
| 刊期 |
5 |
| 页码 |
46-48，57 |
| 关键词 |
Nardosinone; Anti-rheumatoid arthritis; Anti-tumor; Anti-arrhythmia; Anti-depression; Myocardial protection |
| 摘要 |
This paper systematically summarizes the pharmacological effects and molecular mechanisms of nardosinone (Nar) by consulting the literature at home and abroad. The results demonstrate that Nar alleviates the inflammatory response in rheumatoid arthritis by inhibiting the TLR4/MyD88/NF-κB signaling pathway, induces ferroptosis in HT-1080 cells by promoting the accumulation of ROS and lipid peroxides, and exerts antiarrhythmic effects by inhibiting INa, Ito, and ICa-L currents in ventricular myocytes and prolonging their recovery time from inactivation. Moreover, it produces antidepressant effects by reducing the immobility time of mice in behavioral despair models, and protects the myocardium by activating the PI3K/Akt/mTOR pathway to inhibit apoptosis. Nar exhibits multi-target pharmacological activity and has application prospects in the prevention and treatment of autoimmune diseases, tumors, cardiac diseases, and psychiatric disorders. |
