| 刊名 | Medicinal Plant |
| 作者 | Liangyin ZHU， Xiaofeng HAO， Liuqi HUANG， Zongyuan CHEN， Wenfeng CHEN， Liu YANG， Bingchen HUANG， Liyuan LI， Aipeng LI， Suoyi HUANG， Xiuzhen SU |
| 作者单位 | School of Clinical Medicine, Youjiang Medical University for Nationalities； Key Laboratory of Guangxi Universities on National Medicine in Youjiang River, Youjiang Medical University for Nationalities； School of Pharmacy, Youjiang Medical University for Nationalities； Institute of Life Sciences, Youjiang Medical University for Nationalities |
| DOI | 10.19601/j.cnki.issn2152-3924.2024.04.023 |
| 年份 | 2024 |
| 刊期 | 4 |
| 页码 | 101-106 |
| 关键词 | Polygala fallax Hemsl, Gastric motility, Mouse model, Gastric emptying, Gastric paresis, Motilin, Vasoactive intestinal peptide |
| 摘要 | [Objectives] To explore the effects of Polygona fallax Hemsl water extract on gastrointestinal motility in normal mice and gastric motility disorder model mice and approximate mechanism. [Methods] Using normal mice and mice with gastric motility disorders (modeled with atropine), the effects of different mass concentration groups of P. fallax Hemsl water extract (0.125, 0.250, 0.500 g/mL) and domperidone groups on gastric residual rate, small intestine propulsion rate, serum motilin (MLT), vasoactive intestinal peptide (VIP), and tissue morphology were studied. [Results] There was a highly significant difference (P<0.01) in the small intestine propulsion rate of liquid in normal mice among the different concentration groups of P. fallax Hemsl water extract compared to the blank group. The small intestine propulsion rate and gastric residue rate of semi-solid paste were statistically significant compared to the blank group (P<0.05). Among them, there was a highly significant difference between the high concentration group (67.75%±7.65%, 46.5%±10.62%) and the medium concentration group (60.90%±5.87%, 59.27%±7.82%) (P<0.01). There was statistical significance in normal mouse serum MLT content in the high concentration group (P<0.05). There was no effect on serum VIP levels in normal mice; no effect on the morphology of stomach and intestinal tissues of normal mice. The small intestine propulsion rate and gastric residue rate of liquid and semi-solid paste in mice with gastric motility disorders were statistically significant compared to the atropine group, with extremely significant differences (P<0.01). [Conclusions] P. fallax Hemsl water extract has a promoting effect on gastrointestinal motility. One of the specific mechanisms by which P. fallax Hemsl promotes gastrointestinal motility in normal mice may be related to the content of MLT in mouse serum. The mechanism of action in atropine induced gastric paresis mice may be related to the reactivation of M receptors, and the action mechanism of P. fallax Hemsl does not change the original histological basis. It can be inferred that P. fallax Hemsl water extract has a synergistic effect on promoting gastrointestinal motility through other mechanisms, but it is not fully understood and further in-depth research is needed. |
