| 刊名 | Medicinal Plant |
| 作者 | Lihong GUO， Lizhu LIU， Weiwei QIN， Yaxian CHENG |
| 作者单位 | Sleep Psychosomatic Medicine Center, Taihe Hospital, Affiliated Hospital of Hubei University of Medicine |
| DOI | 10.19601/j.cnki.issn2152-3924.2024.04.022 |
| 年份 | 2024 |
| 刊期 | 4 |
| 页码 | 99-100，106 |
| 关键词 | BABL/cJ mice, Shuanghuanglian oral solution, Non-alcoholic steatohepatitis model, Liver function |
| 摘要 | [Objectives] To observe the effect of Shuanghuanglian oral solution on liver function in BABL/cJ mice in non-alcoholic steatohepatitis (NASH) model. [Methods] The BABL/cJ mice were randomly divided into three groups: a control group, a model group, and an experimental group. The experimental group was administered with 10% Shuanghuanglian oral solution at a dose of 0.1 mL/(10 g·d), while the control group and experimental group received an equivalent dosage of normal saline. All three groups were treated for a period of 28 d. The liver function of the mice in each group was examined after the treatment. [Results] The body mass, liver index, triacylglycerol (TG), total cholesterol (TC), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels were all significantly reduced compared to the model group (P<0.05). [Conclusions] Shuanghuanglian oral solution has a beneficial effect on liver function in BABL/cJ mice. |
