| 刊名 | Medicinal Plant |
| 作者 | Pingping TIAN，Wei SHI，Ying PAN，Xiaocong XIANG，Jin CHEN |
| 作者单位 | Anhui Medical College； North Sichuan Medical College |
| DOI | 10.19601/j.cnki.issn2152-3924.2023.04.002 |
| 年份 | 2023 |
| 刊期 | 4 |
| 页码 | 6-8，13 |
| 关键词 | Eriocalyxin B (EriB), Colon cancer, Apoptosis, ERK1/2 |
| 摘要 | [Objectives] To investigate the role of Eriocalyxin B (EriB) in promoting colon cancer cell apoptosis through ERK1/2 pathway in vitro, and to provide a natural candidate drug for colon cancer treatment. [Methods] Colon cancer cells treated with different concentrations of EriB were detected by CCK-8 assay; cell scratch assay and crystal violet staining were used to detect the invasion and migration of colon cancer cell; cell apoptosis was detected by Annexin V/PI double staining, and cell cycle was detected by PI staining; Western Blotting was used to detect epithelial-mesenchymal transition and apoptosis-related proteins in colon cancer cells treated with EriB. [Results] After EriB treatment, the proliferation, migration and apoptosis of colon cancer cells were significantly inhibited, and the ratio of P-ERK1/2 to ERK was significantly decreased. [Conclusions] EriB can effectively inhibit the proliferation of colon cancer cells and promote the apoptosis of colon cancer cells through ERK1/2 pathway. |
