| 摘要 |
[Objectives] To systematically analyze the risk factors for acute kidney injury (AKI) in patients treated with antibiotics and to conduct a meta-analysis of published clinical studies. [Methods] PubMed, Web of Science, and Embase were searched for relevant cohort and case-control studies from January 1, 2001, to October 31, 2022. Meta-analysis was performed using RevMan5.4 and StataMP15. [Results] A total of 22 studies were included. Regarding patient factors, serum creatinine (SCr; MD=1.03, 95% CI of -0.07 to -0.02) was associated with increased antibiotic-associated AKI. Regarding the comorbidities and clinical factors, diabetes (OR=1.34,95% CI of 1.06 to 1.69, tumor (OR=2.07,95% CI of 1.13 to 3.79), pneumonia (OR=1.83,95% CI of 1.24 to 2.71), mechanical ventilation (OR=3.44,95% CI of 1.93 to 6.12), and ICU admission (OR=2.83,95% CI of 2.13 to 3.75) increased the risk of AKI in patients receiving antibiotic therapy. Regarding drug factors, diuretics (OR=2.76,95% CI of 2.16 to 3.52) increased the risk of antibiotic-associated AKI. [Conclusions] This paper may assist clinicians in predicting the risk factors for AKI in patients receiving antibiotic therapy. |
