| 刊名 | Medicinal Plant |
| 作者 | Shengqian TIAN， Enlong WANG， Xin ZHANG， Lili HE |
| 作者单位 | College of Pharmacy, Southwest Minzu University |
| DOI | 10.19601/j.cnki.issn2152-3924.2024.04.009 |
| 年份 | 2024 |
| 刊期 | 4 |
| 页码 | 35-39 |
| 关键词 | Hydroxypropyl tetrahydropyrantriol, Liposome, Lyoprotectant, Lyophilization process |
| 摘要 | [Objectives] To enhance the skin permeability of hydroxypropyl tetrahydropyrantriol and provide a reference for the subsequent prevention or treatment of skin aging. [Methods] The lyophilization process of hydroxypropyl tetrahydropyrantriol liposomes was investigated using a single factor method, and a quality evaluation system was established based on the appearance, particle size, PDI, and re-dispersibility of the lyophilized samples. [Results] The lyophilization process of hydroxypropyl tetrahydropyrantriol liposomes was determined by single factor experiments. The pre-freezing period was 16 h at -80 ℃, the total drying time was 36 h, and the addition of 10% mannitol-sucrose was used as the lyoprotectant. [Conclusions] The product prepared by the lyophilization method exhibits a fluffy and full appearance, with minimal shrinkage and collapse. The volume remains consistent before and after lyophilization, and the re-dispersibility is satisfactory. The re-dissolution process is rapid, and the particle size and polydispersity index (PDI) remain largely unchanged before and after lyophilization. |
