| 刊名 | Medicinal Plant |
| 作者 | Tong LI， Xin XIE， Liyuan LI， Aipeng LI， Zhidong LEI， Tingting HE， Sirui MO， Shangfeng HUANG， Yao LIN， Suoyi HUANG， Lixiang LU， Shiyou ZHOU |
| 作者单位 | School of Basic Medical Sciences,Youjiang Medical University for Nationalities； Key Laboratory of Characteristic Ethnic Medicine Research in Youjiang Basin,Youjiang Medical University for Nationalities； School of Pharmacy,Youjiang Medical University for Nationalities； School of Clinical Medicine,Youjiang Medical University for Nationalities |
| DOI | 10.19601/j.cnki.issn2152-3924.2024.02.013 |
| 年份 | 2024 |
| 刊期 | 2 |
| 页码 | 48-50，56 |
| 关键词 | Buddleja officinalis Maxim.,Tumor cells,Anti-tumor,Activity screening |
| 摘要 | [Objectives]The anti-tumor activity of fractions from Buddleja officinalis Maxim.by petroleum ether,ethyl acetate,n-butanol and water solvent was studied.[Methods]The ethanol extract from B. officinalis Maxim.was extracted and then concentrated with petroleum ether,ethyl acetate,n-butanol and water,respectively,and the extracts were obtained.The inhibitory effects of the four different fractions on the growth of three tumor cell lines in vitro were detected by CCK-8 method,and the median inhibitory concentration (IC50 value) was calculated.[Results]The four fractions inhibited the growth of the three tumor cell lines in vitro,among which the n-butanol fraction had the best anti-tumor activity.The IC50 values of the n-butanol fraction on human gastric cancer (SGC-7901),human breast cancer (MCF-7) and human liver cancer (BEL-7404) cell lines were 0.08,1.58 and 0.12 mg/mL,respectively.[Conclusions]Petroleum ether,ethyl acetate,n-butanol and water fractions from the ethanol extract of B. officinalis Maxim.had certain anti-tumor effects,and the n-butanol fraction had the best anti-tumor activity. |
