| 刊名 | Medicinal Plant |
| 作者 | Tao PAN， Baifang GONG， Zhixia WANG， Hanyu SUN， Xuanle YIN |
| 作者单位 | Key Laboratory of Molecular Pharmacology and Drug Evaluation of the Ministry of Education (Yantai University), School of Pharmacy, Yantai University |
| DOI | 10.19601/j.cnki.issn2152-3924.2024.01.003 |
| 年份 | 2024 |
| 刊期 | 1 |
| 页码 | 13-17 |
| 关键词 | 20 (S)-protopanaxadiol, PLGA nanoparticles, Emulsion solvent evaporation method |
| 摘要 | [Objectives] To prepare 20 (S)-protopanaxadiol PLGA nanoparticles (20(S)-PPD-PLGA-NPs). [Methods] 20 (S)-PPD-PLGA-NPs were prepared by emulsion solvent evaporation method, and the optimal formulation was screened by Box-Behnken experiment with particle size and drug loading as the indicators through single factor experiment, and the drug release in vitro was carried out. [Results] The average diameter of the nanoparticles was (119.60±2.29) nm and the polydispersity index was (0.12±0.02), the size was uniform. The encapsulation efficiency and drug loading of protopanaxadiol were (87.99±1.29)% and (14.86±0.25)%, respectively. [Conclusions] The 20 (S)-PPD-PLGA-NPs were successfully prepared by emulsion solvent evaporation method, and the 20 (S)-PPD-PLGA-NPs had good stability, to lay a foundation for the study of 20 (S)-PPD-PLGA-NPs in vitro and in vivo. |
