| 刊名 | Medicinal Plant |
| 作者 | Xuemei LU, Wanyu ZUO, Yun LI, Weiyu WANG, Ruyin DONG, Luyang LU,Jizhong Zhang |
| 作者单位 | College of Pharmacy, Southwest Minzu University;University of Tibetan Medicine |
| DOI | 10.19601/j.cnki.issn2152-3924.2023.06.008 |
| 年份 | 2023 |
| 刊期 | 6 |
| 页码 | 35-38，42 |
| 关键词 | Plumbagin, Nanomicelle, In-situ gel, Preparation process |
| 摘要 | [Objectives] To prepare plumbagin nanomicelle (PLB-N) in-situ gel, and optimize the formulation and process. [Methods] PLB-N was prepared by self-assembly method, and the optimal formulation of PLB-N in-situ gel was determined by orthogonal experiment design and single factor method. [Results] The optimal preparation process for PLB-N was a drug to lipid ratio of 1∶3, a Tween 80 content of 5%, an ethanol content of 7.5% of the hydration medium, a magnetic stirring speed of 2 200 rpm, a stirring time of 30 min, and an ultrasound time of 10 min. The optimal formulation of PLB-N in-situ gel was 22% of poloxamer 407, 6% of poloxamer 188, and 1∶1 of PLB-N to water. The encapsulation efficiency of PLB-N prepared with the optimal formula was (95.8%±0.4%), and the average particle size was (75.19±1.14) nm, and the Zeta potential was (-20.73 ±1.19) mv. [Conclusions] PLB-N in-situ gel had stable and reliable preparation process, uniform content, and broad application prospects. |
