| 刊名 | Medicinal Plant |
| 作者 | Zhaojun XIANG, Xia ZHANG, Chaoyang TANG, Qianqian LUO, ShengYueqin GONG, Hui HU, Chaoyan ZHU |
| 作者单位 | Department of Neurosurgery, Taihe Hospital (Affiliated Hospital of Hubei University of Medicine), Shiyan 442000, China |
| DOI | DOI:10.19600/j.cnki.issn2152-3924.2026.03.014 |
| 年份 | 2026 |
| 刊期 | 3 |
| 页码 | 68-69 |
| 关键词 | Shenfu Injection, Acute cerebral infarction, Regional cerebral blood flow, Electroencephalogram, Spike, Rats |
| 摘要 | [Objectives] To observe the effect of Shenfu Injection on regional cerebral blood flow (RCBF) in a rat model of acute cerebral infarction. [Methods] Thirty Sprague-Dawley (SD) rats were randomly assigned to three groups: control group, model group, and Shenfu Injection group (administered via tail vein injection at 2 mL/100 g body weight). The model was established using the middle cerebral artery occlusion (MCAO) method, and electroencephalogram (EEG) spike amplitude and RCBF were measured at 0, 30, and 60 min, as well as 1, 3, and 6 d post-reperfusion. [Results] Compared with the model group, the Shenfu Injection group exhibited significantly increased RCBF on day 3 and 6 (P<0.05) and significantly decreased EEG spike amplitude on day 1, 3, and 6 (P<0.05). [Conclusions] Shenfu Injection improves regional cerebral blood flow in rats with acute cerebral infarction, potentially through mechanisms involving suppression of abnormal electrical discharges and dilatation of microvessels. |
