| 刊名 | Medicinal Plant |
| 作者 | Hongye LI, Xichun HUANG, Quan QUAN, Junhao LI, Zhao NING, Wenhui ZHAO, Chenghao JIN |
| 作者单位 | College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing 163319, China |
| DOI | DOI:10.19600/j.cnki.issn2152-3924.2026.03.006 |
| 年份 | 2026 |
| 刊期 | 3 |
| 页码 | 22-25，35 |
| 关键词 | Harmine, Anti-tumor, Anti-inflammatory, Antibacterial, Anti-echinococcosis, Osteogenic differentiation, Neuroprotective |
| 摘要 | This paper provides a systematic review of the anti-tumor, anti-inflammatory, antibacterial, and anti-echinococcosis effects of harmine, as well as its role in regulating osteogenic differentiation and protecting the central nervous system, along with the underlying molecular mechanisms. Harmine exhibits anti-tumor properties by inhibiting the proliferation of gastric cancer, lung cancer, and other cancer cell types, inducing apoptosis, and impeding migration and invasion through pathways such as PTEN/AKT/MDM2. Regarding its anti-inflammatory and antibacterial effects, harmine reduces inflammation by modulating the NF-κB/NLRP3 pathway and exerts antibacterial activity by disrupting bacterial structures. Furthermore, harmine regulates the Th1/Th2 balance to produce anti-echinococcosis effects, promotes osteogenic differentiation by mediating the antioxidant activity of CA-9, and ameliorates anxious behavior through the regulation of neuroinflammation. This review offers a theoretical foundation for the further development and clinical application of harmine. |
