| 刊名 | Medicinal Plant |
| 作者 | Lifu WEI, Shengbin CHEN, Xiren ZHENG, Xiumei MA, Bing QING, Zhenying FU, Wen ZHONG |
| 作者单位 | The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China; Guangxi International Zhuang Medical Hospital, Nanning 530201, China |
| DOI | DOI:10.19600/j.cnki.issn2152-3924.2026.03.003 |
| 年份 | 2026 |
| 刊期 | 3 |
| 页码 | 11-14 |
| 关键词 | Guichen Xuanfei Mixture, Extraction process, Preparation method |
| 摘要 | [Objectives] To optimize the extraction and preparation processes of Guichen Xuanfei Mixture and establish a foundation for its industrial-scale production. [Methods] Using the dry paste rate as the evaluation index, a single-factor experiment was conducted to examine the effects of soaking time, volume of water added, and extraction duration. Subsequently, orthogonal experiments were employed to optimize the volume of water added, extraction duration, and extraction frequency. Following the determination of the optimal extraction process, process validation tests and pilot-scale production were performed. [Results] The optimal extraction process involved soaking the medicinal materials in water for 30 min, followed by two successive boiling steps. During the first extraction, 8 times the volume of water relative to the material was used, and 6 times the volume was applied during the second extraction. Each extraction was conducted for 1 h. The average dry paste rate obtained from the verification test was 24.25%, while the yield rates for the three batches of pilot-scale production were 93.6%, 93.9%, and 93.6%, respectively. [Conclusions] The optimized extraction and preparation method is rational, stable, and demonstrates excellent reproducibility, making it well-suited for the industrial-scale production of Guichen Xuanfei Mixture. |
