| 刊名 | Medicinal Plant |
| 作者 | Junchen GU, Xiong CHEN, Conghui WANG, Chunqi AI |
| 作者单位 | Mental Health Center, Shiyan Taihe Hospital (Hubei University of Medicine), Shiyan 442000, China |
| DOI | DOI:10.19600/j.cnki.issn2152-3924.2026.02.016 |
| 年份 | 2026 |
| 刊期 | 2 |
| 页码 | 72-74，86 |
| 关键词 | Bipolar disorder, Bipolar depression, Antidepressants, Drug-induced mania, Mood stabilizers |
| 摘要 | Drawing on recent evidence from large cohort studies and meta-analyses, this review summarizes advances in the use of antidepressants for bipolar depression. It focuses on the incidence and risk factors of drug-induced mania and compares the efficacy and safety profiles of various antidepressant classes. Available evidence indicates that the risk of antidepressant-associated mania may be lower than previously believed, and short-term efficacy has been partially supported. Nevertheless, long-term treatment strategies, risk-benefit assessments, and individualized prescribing require further validation through high-quality studies. This article aims to inform clinical decision-making and guide future research in the management of bipolar depression. |
