| 刊名 | Medicinal Plant |
| 作者 | Qin ZENG, Guangying DU |
| 作者单位 | School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China |
| DOI | DOI:10.19600/j.cnki.issn2152-3924.2026.02.015 |
| 年份 | 2026 |
| 刊期 | 2 |
| 页码 | 66-71 |
| 关键词 | 5-HT2AR, Schizophrenia, Depression, Alzheimer's Disease, Anxiety Disorders, Drug Addiction, Sleep-Wake Cycle |
| 摘要 | This article systematically reviews the structure, distribution, and signal transduction mechanisms of the 5-HT2AR, with a particular focus on the association between its dysfunction and the pathogenesis of various central nervous system (CNS) disorders, including schizophrenia, depression, Alzheimer's disease, anxiety disorders, drug addiction, and sleep disorders. It further elaborates on the mechanisms of action and research progress of various drugs targeting the 5-HT2AR (such as atypical antipsychotics, selective antagonists, and inverse agonists) in the treatment of these disorders. This review aims to provide insights for a deeper understanding of the pathophysiological functions of the 5-HT2AR and for the development of more effective therapeutics for neuropsychiatric diseases. |
