| 刊名 | Medicinal Plant |
| 作者 | Min YE, Shengxin ZHANG, Faying YUE, Yong XIANG |
| 作者单位 | Department of Pain Management, Taihe Hospital (Affiliated Hospital of Hubei University of Medicine), Shiyan 442000, China |
| DOI | DOI:10.19600/j.cnki.issn2152-3924.2026.02.008 |
| 年份 | 2026 |
| 刊期 | 2 |
| 页码 | 33-34，40 |
| 关键词 | Rat, Dachaihu Decoction, Ulcerative colitis, Visceral pain behavior, Intestinal motility |
| 摘要 | [Objectives] To investigate the mechanism by which Dachaihu Decoction affects visceral pain behavior in a rat model of ulcerative colitis (UC). [Methods] Twenty-one male Sprague-Dawley (SD) rats were randomly and equally divided into a control group, a UC group, and a Dachaihu Decoction group (n=7 per group). After treatment completion, visceral pain behavior and colonic motility indices were assessed using in vivo colorectal distension (CRD) and abdominal withdrawal reflex (AWR) tests. [Results] Compared to the UC group, the Dachaihu Decoction group exhibited increased colon length, elevated colonic basal tension, heightened peak contractile tension, and increased contraction frequency. These differences were statistically significant (P<0.05). [Conclusions] Dachaihu Decoction may ameliorate visceral hyperalgesia induced by rectal distension stimuli in the UC rat model by improving colonic motility. |
