| 刊名 | Medicinal Plant |
| 作者 | Demei HU, Wenyu MA, Jianlian SHI, Leizhuang YANG, Yan SHEN, Jia LIU |
| 作者单位 | Kunming Medical University Haiyuan College, Kunming 650106, China |
| DOI | DOI:10.19600/j.cnki.issn2152-3924.2026.02.003 |
| 年份 | 2026 |
| 刊期 | 2 |
| 页码 | 12-15 |
| 关键词 | Clerodendranthus spicatus，Fractionation，Uric acid-lowering，Hyperuricemia |
| 摘要 | [Objectives] To investigate the uric acid-lowering effects of Clerodendranthus spicatus (Thunb.) C.Y.Wu ex H.W. Li. [Methods] After the optimization and scale-up of C. spicatus extraction, HP-20 macroporous resin was employed for fractionation using four eluents with ethanol concentrations of 10%, 40%, 70%, and 95%, yielding fractions designated as Fr.1 to Fr.4. The pharmacological effects of these fractions (Fr.1–Fr.4) were subsequently investigated in hyperuricemic model animals. [Results] Fr.1–Fr.4 reduced the serum levels of uric acid (UA), xanthine oxidase (XOD), blood urea nitrogen (BUN), and creatinine (CRE) in hyperuricemic rats, with Fr.4 demonstrating the optimal effect. All fractions increased body weight, decreased renal index, and exhibited certain protective effects against renal injury. [Conclusions] C. spicatus exhibits anti-hyperuricemic activity by reducing serum uric acid levels and also displays obvious renal protective effects. |
