| 摘要 |
[Objectives] To investigate the mechanism of action by which the traditional Chinese medicine (TCM) compound Cang Er Zi Nasal Relief patch alleviates nasal inflammation through network pharmacology. [Methods] The active ingredients and target sites of the Cang Er Zi Nasal Relief patch formulation were screened and collected through a comprehensive literature review and analysis of the TCMSP database. Target sites associated with nasal inflammatory diseases were obtained from the TTD, OMIM, and GeneCards databases. String database analysis was performed to identify common targets between active ingredients and diseases. Cytoscape software was used to construct network diagrams, facilitating the identification of core active ingredients and target molecules in the herbal patch formulation. Additionally, the DAVID database was employed to perform Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on the identified target molecules. [Results] The core herbal ingredients of the Cang Er Zi Nasal Relief patch may include Baical Skullcap Root, Centipeda minima, Divaricate Saposhnikovia Root, Cablin Potchouli Herb, Magnoliae Flos, and Menthae Herba. The core active ingredients likely include apigenin, luteolin, oxypeucedanin, emodin, rosmarinic acid, etc., which contribute to the alleviation of nasal inflammation. The core action targets may involve ESR2, TNF-α, AKT1, IL-4, MPO, and IL-6. The active ingredients in the health patch may alleviate nasal inflammation and associated symptoms like rhinorrhea, nasal itching, congestion, and dryness by targeting signaling pathways including IL-17, TNF, JAK-STAT, PI3K-Akt, and NF-κB within the body. [Conclusions] The clear and verifiable chain of action—“topical patches, transdermal absorption of active ingredients, regulation of core pathways, and alleviation of inflammatory symptoms”—provides robust molecular biological evidence supporting the clinical application of TCM in the external treatment of nasal disorders. |
