| 刊名 | Medicinal Plant |
| 作者 | Haoyang LI， Xingyu LIU， Xiaomei LIANG， Lixuan PAN， Liting ZHAO， Canxin YAN， Yanyang LI， Liangna SU， Xiaoyi HUANG， Suoyi HUANG， Ran CHEN |
| 作者单位 | School of Clinical Medicine, Youjiang Medical University for Nationalities； School of Pharmacy, Youjiang Medical University for Nationalities； School of Basic Medical Sciences, Youjiang Medical University for Nationalities； School of Life Sciences, Youjiang Medical University for Nationalities |
| DOI | DOI: 10.19600/j.cnki.issn2152-3924.2025.06.014 |
| 年份 | 2025 |
| 刊期 | 6 |
| 页码 | 69-71 |
| 关键词 | Erchen decoction, Doxofylline, Compatibility, Chronic obstructive pulmonary disease (COPD), IL-6, Changes in body weight |
| 摘要 | [Objectives] To explore the therapeutic effects of doxofylline combined with Erchen decoction in chronic obstructive pulmonary disease (COPD) model rats and its impact on serum IL-6 levels. [Methods] Rats were divided into seven groups: blank, model, Erchen decoction, doxofylline, and combined medication groups at low, medium, and high doses. After successful modeling, they were administrated intragastrically at the respective doses for 4 weeks. [Results] Compared to the control group, serum IL-6 levels in the Erchen decoction group and the combined medication groups at low and medium doses were significantly decreased (P<0.05). Additionally, the body weight of rats after treatment was significantly increased compared to before treatment (P<0.05). [Conclusions] Doxofylline combined with Erchen decoction can reduce serum IL-6 levels in COPD rats, improve their body weight, and exert a therapeutic effect on COPD. |
