| 作者单位 |
Guangxi University of Chinese Medicine,Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,University Engineering Research Center of Development and Industrialization of Zhuang and Yao Ethnic Medicinal Materials ,Guangxi,The Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine,Guangxi Engineering Research Center of Ethnic Medicine Resources and Application |
| 摘要 |
[Objectives] To investigate the protective effects of xanthoxylin on acute lung injury induced by D-Galactosamine (D-GalN) and Lipopolysaccharide (LPS) in rats. [Methods] Sixty male SD rats were randomly divided into a normal group, a model group, a silybin group (50 mg/kg), and three xanthoxylin groups (low-dose, medium-dose, high-dose as 60, 120, and 240 mg/kg), 10 rats per group. The rats were administered for 17 consecutive days, on day 14, all the rats except for the normal group were intraperitoneally injected with a D-GalN (400 mg/kg) /LPS (30 μg/kg) mixture once to establish acute lung injury models. At 72 h after modeling, their serum MCP-1 levels, IL-1β, IL-6, PCT, CRP, TNF-α levels in bronchoalveolar lavage fluid, and IL-1β, IL-6, TNF-α levels in lung tissue were measured, and lung tissue histological examination were checked by HE staining. [Results] Compared with the model group, the serum MCP-1 levels, IL-1β, IL-6, PCT, CRP, TNF-α levels in bronchoalveolar lavage fluid, and IL-1β, IL-6, TNF-α levels in lung tissue in xanthoxylin groups were significantly decreased (P<0.05 or P<0.01), and lung tissue injury were alleviated. [Conclusions] Xanthoxylin has protective effects on acute lung injury in rats, and it may be related to the increase of anti-inflammatory capacity and the promotion of lung tissue self-healing. |
