| 摘要 |
[Objectives] To investigate the impact of the compatibility of Bombax malabaricum flowers and Osmanthus fragrans on the analgesic therapeutic effects in mice. [Methods] The analgesic effects of B. malabaricum flowers and O. fragrans, as well as their compatibility at a 1：1 ratio, were investigated using the hot plate test and the acetic acid writhing test. Observations were made regarding the reactions of mice, specifically the licking of their forepaws and hindpaws, both prior to and following drug administration. The duration of these reactions was recorded, and the pain threshold of the mice was assessed following drug administration. Additionally, the frequency of writhing responses was documented following the injection of acetic acid into the abdominal cavity of the mice for 20 min. [Results] The pain thresholds observed in the positive control group, the B. malabaricum flowers group, the O. fragrans group, and the compatibility group were significantly elevated compared to those of the blank control group following 14 d of drug administration (P<0.05). This finding indicates that the positive control group, the B. malabaricum flowers group, the O. fragrans group, and the compatibility group of B. malabaricum flowers and O. fragrans at a 1：1 ratio exhibited analgesic efficacy in mice. Furthermore, the pain thresholds of the B. malabaricum flowers and O. fragrans groups were significantly lower than that of the compatibility group (P<0.05), suggesting that the compatibility group demonstrated a significantly superior analgesic effect compared to the B. malabaricum flowers group in mice. A statistically significant difference was observed in the frequency of writhing responses among the five experimental groups： the normal saline group, the positive control group, the B. malabaricum flowers group, the O. fragrans group, and the compatibility group (P=0.01<0.05). Post hoc analyses revealed that the frequency of writhing responses in the O. fragrans group was significantly lower than that observed in both the normal saline group and the compatibility group. Additionally, the frequency of writhing responses in the positive control group was significantly lower than that in the normal saline group. [Conclusions] B. malabaricum flowers and O. fragrans, as well as their compatibility at a 1：1 ratio, exhibits analgesic effects, with the analgesic effect being more pronounced in the compatibility group compared to the B. malabaricum flowers group or the O. fragrans group. |
