| 刊名 | Medicinal Plant |
| 作者 | Xiaowu TANG |
| 作者单位 | Shanghai Taoshu Biotechnology Co.,Ltd. |
| DOI | 10.19601/j.cnki.issn2152-3924.2025.05.005 |
| 年份 | 2025 |
| 刊期 | 5 |
| 页码 | 19-21，28 |
| 关键词 | Small molecule inhibitor, PD-L1, Immune checkpoint, Synthetic process |
| 摘要 | [Objectives] To explore the synthetic process of PD-L1 small molecule inhibitors, focusing on optimizing key reaction conditions and synthetic routes. [Methods] By analyzing the pharmacophore design of PD-L1 small molecule inhibitors and combining the optimization of synthetic methods and the improvement of reaction conditions, an efficient synthetic process was developed. [Results] Through optimization of reaction conditions, not only were the purity and yield of the products improved, but the inhibitory activity of the compounds was also significantly enhanced. Some compounds demonstrated strong anti-tumor effects in both in vitro and in vivo models. [Conclusions] This study aims to provide theoretical support and technical guidance for the efficient synthesis of small molecule inhibitors, offering new ideas and practical foundations for drug development in tumor immunotherapy. |
