| 摘要 |
[Objectives] To investigate the antibacterial mechanism of Common Cnidium Fruit using network pharmacology. [Methods] Active components and targets of Common Cnidium Fruit were screened and obtained using the TCMSP database and HIT2.0 database. The collected targets were intersected with antibacterial/bacteriostatic targets obtained from the GeneCards database and OMIM database to identify the antibacterial/bacteriostatic targets of Common Cnidium Fruit. The active component-target network diagram of Common Cnidium Fruit was constructed using Cytoscape software and topological analysis was performed. GO enrichment analysis was performed on the target genes using the DAVID database. [Results] Screening yielded 25 active components of Common Cnidium Fruit, corresponding to 77 targets. Analysis identified 25 core antibacterial/bacteriostatic targets for Common Cnidium Fruit. Network analysis indicated that Common Cnidium Fruit may exert antibacterial/bacteriostatic effects through active components such as β-sitosterol, stigmasterol, and xanthoxylin, while activating the body’s immune regulatory functions by acting on targets including CASP3, PTGS2, BCL2, JUN, and ESR1. [Conclusions] Common Cnidium Fruit may exert antibacterial/bacteriostatic effects through multiple pathways via a mechanism involving multiple components, multiple targets, and multiple pathways. |
