| 摘要 |
[Objectives] To investigate the impact of aluminium on secretase activity. [Methods] A total of 60 Kunming mice were divided into three groups: a control group, a medium-dose model group, and a high-dose model group, with 20 mice in each group. All groups, except for the control group, received sequential injections of aluminum maltolate. The dosage for each injection was 0.3 and 0.45 mL per mouse, administered once daily. An injection pause of 2 d was observed every 5 d throughout the duration of the experiment, which lasted for a total of 40 d. At the conclusion of the study, blood samples were collected to isolate serum, and the brains were taken to prepare a 10% brain homogenate for subsequent analysis. [Results] The activities of brain β-secretase were 11.08±1.65, 11.94±1.37▲, and 12.32±0.93▲ u/L, respectively, with an F-value of 4.290 and a P-value of 0.018. When compared to the control group, the differences were statistically significant, as indicated by ▲P<0.05. The activities of α-secretase were 23.02±3.52, 19.04±1.10▲, and 18.44±1.40▲▲ u/L, respectively, yielding an F-value of 5.972 and a P-value of 0.016. Comparisons with the control group revealed statistically significant differences, as denoted by ▲P<0.05 and ▲▲P<0.01. The activities of γ-secretase were 11.01±2.05▲▲, 10.38±1.94▲, and 9.00±1.62 u/L, respectively, with an F-value of 5.780 and a P-value of 0.005. When compared to the high-dose group, the differences were statistically significant, with ▲P<0.05 and ▲▲P<0.01. [Conclusions] Aluminium exerts a considerable influence on the activities of brain β, α, and γ-secretases. |
