| 摘要 |
[Objectives] To investigate the potential applications and mechanisms of action of medicinal plants as bacteriostatic agents, utilizing snow lotus as a case study through network pharmacology. [Methods] The TCMSP and HIT 2.0 databases were employed to screen and obtain the active components and corresponding targets of snow lotus. The identified targets were subsequently intersected with the antibacterial and bacteriostatic targets sourced from the GeneCards and OMIM databases, resulting in the identification of the antibacterial and bacteriostatic targets associated with snow lotus. Cytoscape software was employed to construct the network diagram illustrating the active components and their corresponding action targets for snow lotus, as well as to analyze the network’s topology. Additionally, GO enrichment analysis of the action targets was conducted utilizing the DAVID database. [Results] A total of 12 active components of snow lotus were identified through screening, which corresponded to 294 action targets. Subsequent analysis revealed 117 core action targets of snow lotus that exhibit antibacterial and bacteriostatic properties. The results from the network diagram suggested that snow lotus may exert its antibacterial and bacteriostatic effects through active components such as quercetin, apigenin, and luteolin. Additionally, it appeared to activate the immunomodulatory functions of the human body by interacting with targets such as CASP3, TNF, and IL-6. [Conclusions] Snow lotus may demonstrate antibacterial and bacteriostatic properties through mechanisms of action that involve multiple components, targets, and pathways, from in vivo and in vitro multiple pathways. The integration of botanical bacteriostatic agents with chemical disinfectants that possess broad-spectrum bactericidal effects is advantageous for broadening the bactericidal spectrum and minimizing irritation, in order to facilitate the development of more environmentally friendly and low-toxicity disinfection and bacteriostatic products. |
