| 刊名 | Medicinal Plant |
| 作者 | Wenxia ZHANG， Lifeng TIAN， Zhien WANG， Li LIU |
| 作者单位 | Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine； Xiushui County First People's Hospital |
| DOI | 10.19601/j.cnki.issn2152-3924.2025.03.005 |
| 年份 | 2025 |
| 刊期 | 3 |
| 页码 | 20-21，31 |
| 关键词 | Castanopsis sclerophylla (Lindl) Schottk fruit, Diarrhea, Action mechanism |
| 摘要 | ［Objectives］ To explore the pharmacodynamic effect of the Castanopsis sclerophylla (Lindl) Schottk fruit on diarrhea model mice. [Methods] The anti-diarrheal efficacy of the C. sclerophylla fruit was evaluated using a castor oil-induced acute diarrhea model in mice and the small intestinal charcoal propulsion test, with assessment of onset time of diarrhea, frequency of loose stools, and small intestinal propulsion rate. [Results] Compared with the model group, the C. sclerophylla frui-treated group demonstrated significantly delayed onset of diarrhea, reduced frequency of loose stools, and decreased small intestinal charcoal propulsion rate in a dose-dependent manner, with the high-dose group achieving efficacy comparable to the loperamide-treated group. [Conclusions] The C. sclerophylla fruit has certain anti-diarrhea effect, and its anti-diarrhea mechanism may be related to the inhibition of small intestinal peristalsis. |
