| 刊名 | Medicinal Plant |
| 作者 | Yueping ZHI， Kefeng ZHANG， Ya GAO， Bo LI， Houkang CAO |
| 作者单位 | Key Laboratory of Pharmacology for Prevention and Treatment of High Incidence Diseases in Guangxi Higher Education Institutions, Guilin Medical University |
| DOI | 10.19601/j.cnki.issn2152-3924.2025.02.012 |
| 年份 | 2025 |
| 刊期 | 2 |
| 页码 | 55-57，61 |
| 关键词 | Cholestasis, Steatosis, Schaftoside |
| 摘要 | [Objectives] To explore the target and mechanism of Schaftoside on cholestasis and steatosis based on network pharmacology and molecular docking. [Methods] The targets of "cholestasis" and "steatosis" were predicted using databases (OMIM and GeneCards), and the key targets were obtained after screening the retrieval data. The binding relationship between Schaftoside and key targets was analyzed by molecular docking. [Results] There were 3 370 and 4 433 targets for "cholestasis" and "steatosis", respectively, and 1 767 overlapping genes were obtained. The results of molecular docking showed that Schaftoside had high binding energy with key targets. [Conclusions] Schaftoside can alleviate cholestasis and steatosis by regulating SREBP-1, CYP7, PPAR-gamma and other key targets to protect liver. |
