| 摘要 |
[Objectives] To investigate the effect of extract A from Blumea megacephala (Randeria) Chang et Tseng on the hemostasis of postpartum uterine hemorrhage in early pregnancy rats. [Methods] 12 mg/kg of mifepristone and 120 μg/kg of misoprostol were used to establish the uterine bleeding model of early pregnancy rats, and the effects of the drugs on the amount of uterine bleeding, the contents of angiotensin II (Ang-II) and prostaglandin E2 (PGE2) in serum, the four factors of coagulation, platelet adhesion, platelet aggregation and platelet number were investigated. [Results] Extract A can shorten prothrombin time (PT) and activated partial thromboplastin time (APTT) in rats. It can reduce the amount of uterine bleeding in the model, reduce the contents of PGE2 and Ang-II, reduce APTT and PT, increase the content of fibrinogen FIB, enhance platelet adhesion, enhance platelet aggregation and increase the number of platelets. [Conclusions] Extract A has obvious hemostatic effect on uterine bleeding model of early pregnancy rats. It may play a hemostatic role by affecting vasoconstriction-dilation, coagulation factors in the blood’s internal and external coagulation system, platelet adhesion and aggregation, increasing FIB content, increasing platelet number, affecting uterine bleeding, etc., showing the characteristics of multiple pathways and multiple targets. |
