| 摘要 |
[Objectives]To compare the clinical efficacy and cost-effectiveness of Yangxin Dingji capsule in conjunction with conventional Western medicine therapy against the use of conventional Western medicine therapy alone in the treatment of tachyarrhythmia.[Methods]A meta-analysis was conducted to evaluate the efficacy of Yangxin Dingji capsule in conjunction with conventional Western medicine therapy for the treatment of tachyarrhythmia,compared to conventional Western medicine therapy alone.A decision tree model was developed to conduct a cost-effectiveness analysis from the perspective of the healthcare system.The effect parameter was the clinical effectiveness rate obtained from a meta-analysis of clinical literature.The cost parameter was represented by the drug treatment cost.The incremental cost-effectiveness ratio (ICER) was subsequently calculated,and the robustness of the primary analysis results was assessed through one-way sensitivity analysis.[Results]The results of the meta-analysis indicated that,over an 8-week treatment period,the clinical efficacy of Yangxin Dingji capsule in conjunction with conventional Western medicine for the treatment of tachyarrhythmia was superior to that of conventional Western medicine therapy alone,and the difference was found to be statistically significant[OR=3.32,95% CI (2.22-4.96),P<0.000 01].The clinical efficacy of Yangxin Dingji capsule in conjunction with conventional Western medicine for the treatment of tachyarrhythmia was found to be superior when the treatment duration was 4 weeks,and the difference was found to be statistically significant[OR=2.39,95% CI (1.45-3.96),P=0.000 7].The cost-effectiveness analysis indicated that with an 8-week treatment regimen,each 1% increase in the clinical effectiveness rate of Yangxin Dingji capsule in conjunction with conventional Western medical therapy for the treatment of arrhythmia,as compared to conventional Western medical therapy alone,resulted in an increase in cost of 91.78 yuan.Conversely,when the treatment duration was 4 weeks,each 1% increase in the clinical effectiveness rate of the Yangxin Dingji capsule combined with conventional Western medical therapy led to a cost increase of 70.84 yuan.[Conclusions]In the management of tachyarrhythmia,the clinical efficacy of Yangxin Dingji capsule in conjunction with conventional Western medicine therapy is superior to that of conventional Western medicine therapy alone.When the willingness-to-pay value exceeds the corresponding ICER,the combination of Yangxin Dingji capsule with conventional Western medicine therapy is deemed more cost-effective than the use of conventional Western medicine therapy alone. |
