Advances in the Pathogenesis of Severe Acute Pancreatitis
刊名 Agricultural Biotechnology
作者 Jiayang LI1#, Liuxian TANG2#, Yuting WEI1, Kexin HOU1, Yongwen LI3*
作者单位 1. College of Pharmacy, Guilin Medical University, Guilin 530200, China; 2. College of Basic Medical Sciences, Guilin Medical University, Guilin 530200, China; 3. Department of Pharmacology, College of Pharmacy, Guilin Medical University, Guilin 541199, China
DOI DOI:10.19759/j.cnki.2164-4993.2026.03.013
年份 2026
刊期 3
页码 67-71
关键词 Severe acute pancreatitis; Molecular mechanism; Cellular inflammation; Microcirculatory disturbance
摘要 Severe acute pancreatitis (SAP), the most severe and prognostically poorest form of acute pancreatitis (AP), is characterized by rapid onset, swift disease progression, diverse complications, and a high mortality rate. In recent years, influenced by changes in dietary structure and the rising prevalence of metabolic diseases, the incidence of SAP has shown a continuous increasing trend. This paper reviews and summarizes the main pathogenic mechanisms and recent research progress on SAP, hoping to provide a reference for early disease identification, risk assessment, and targeted therapy.