| 摘要 |
Burn infection is one of the most common and severe complications in burn patients and a major factor contributing to high mortality rates. The loss of skin barrier function and the immunosuppressive state following burns make patients highly susceptible to wound infections, which can progress to systemic sepsis. Although burn wounds are initially sterile, they are rapidly colonized by Gram‑positive bacteria (e.g., Staphylococcus aureus) within a short period, followed by colonization with Gram‑negative bacteria (e.g., Pseudomonas aeruginosa), thereby increasing therapeutic challenges. Current clinical management relies on a multidisciplinary collaborative approach, combining conventional antibiotics, emerging therapies, and comprehensive care strategies. Among these methods, early intervention, precise treatment administration, and prevention and control are critical to improving patient survival and prognosis. In recent years, drug-loaded hydrogels, as a class of wound repair materials characterized by biocompatibility, controlled drug release, and multifunctional integration, have demonstrated significant advantages in the treatment of burn infections. They can effectively inhibit pathogenic microorganisms, alleviate inflammation, and promote tissue regeneration. This review systematically summarizes recent research advances in the application of drug‑loaded hydrogels for the treatment of infected burn wounds, aiming to provide a reference for their further development and clinical translation. |
