| 刊名 | Agricultural Biotechnology |
| 作者 | Meshack Chubwa Maguru1, Shiqi WEI1, Xi CHEN1,2,, Mingxiao LI1, Shunlong MENG1,2*, Emmanuel Godfrey Maneno3 |
| 作者单位 | 1.Wuxi Fishery College, Nanjing Agricultural University, Wuxi 214081, China; Scientific Observing and Experimental Station of Fishery Resource and Environment in the Lower Reaches of the Changjiang River, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China |
| DOI | DOI:10.19759/j.cnki.2164-4993.2025.06.011 |
| 年份 | 2025 |
| 刊期 | 6 |
| 页码 | 53-55,64 |
| 关键词 | Acute toxicity; Joint toxicity; Lambda-cyhalothrin; Cypermethrin; Oreochromis niloticus |
| 摘要 | The extensive co-occurrence of pyrethroid insecticides like lambda-cyhalothrin (LCT) and cypermethrin (CPM) in aquatic systems poses a potential risk, yet a significant research gap exists regarding their combined toxicological effects. In this study, the single and joint acute toxicity effects of lambda-cyhalothrin (LCT) and cypermethrin (CPM) on Nile tilapia fingerlings were investigated using 96-hour bioassays. Results showed both were highly toxic, with LCT (96-h LC50 = 66.53 µg/L) being four-fold more potent than CPM (259.41 µg/L). Regression analysis confirmed positive correlation (P<0.01) between pesticide concentration and observed mortality. The binary mixture exhibited synergistic effect with Additive Index (AI) > 0, indicating combined effects exceeded the sum of their individual actions. This synergism likely stems from mutual inhibition of metabolic detoxification pathways, leading to increased internal concentrations and amplified neurotoxicity. Generally, this study confirmed that single-compound risk assessments dangerously underestimate pyrethroid mixture hazards, necessitating their inclusion in regulatory frameworks for accurate aquatic biodiversity protection. |
