Pharmacological Effects of Lupeol: Antitumor, Anti-inflammatory, Antioxidant, and Antidiabetic Activities
| 刊名 |
Asian Agricultural Research |
| 作者 |
Jiaru YE， Huizhen PEI， Shuang REN， Linbo JIA， Junhao LI， Chenghao JIN |
| 作者单位 |
College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University |
| DOI |
10.19601/j.cnki.issn1943-9903.2026.08.005 |
| 年份 |
2026 |
| 刊期 |
8 |
| 页码 |
29-32，42 |
| 关键词 |
Lupeol, Anti-tumor, Anti-inflammatory, Antioxidant, Type 2 diabetes mellitus |
| 摘要 |
Lupeol (LUP) is a natural triterpenoid compound derived from various plants, exhibiting pharmacological effects including tumor inhibition, inflammation suppression, antioxidant activity, and amelioration of type 2 diabetes mellitus. In terms of anti-tumor activity, LUP inhibits breast cancer by inducing ROS accumulation, suppresses liver cancer by inhibiting the Wnt/β-catenin pathway, exerts anti-lung cancer effects by regulating the Notch pathway, and blocks the colon cancer cell cycle by inhibiting the RhoA-ROCK1 pathway. In terms of anti-inflammatory activity, LUP alleviates osteoarthritis by activating the SIRT3/mTOR pathway to enhance autophagy. In terms of antioxidant activity, LUP alleviates oxidative stress and inflammation to protect against myocardial injury. Additionally, LUP improves type 2 diabetes mellitus by regulating glucose and lipid metabolism and protecting islet β-cells. LUP has high safety and multi-target regulatory effects. However, its specific molecular mechanisms and clinical studies still require further in-depth exploration. |
