| 刊名 | Asian Agricultural Research |
| 作者 | Hui WANG, Mengyun WANG, Yanzhen ZUO, Yuhong LI |
| 作者单位 | Cancer Research Laboratory, Chengde Medical University |
| DOI | 10.19601/j.cnki.issn1943-9903.2026.07.010 |
| 年份 | 2026 |
| 刊期 | 7 |
| 页码 | 63-68 |
| 关键词 | Atractylodes lancea, Chronic pancreatitis (CP), Network pharmacology, Molecular docking |
| 摘要 | [Objectives] To explore the mechanism of Atractylodes lancea in the treatment of chronic pancreatitis (CP). [Methods] The network pharmacology and molecular docking techniques were applied. The active components of A. lancea were screened through the TCMSP database, and the potential targets of A. lancea were predicted using the SwissTargetPrediction database. Disease-related targets of chronic pancreatitis were collected from the GeneCards and OMIM databases. Cytoscape software was used to construct and analyse the “drug component–target” network. The intersecting targets between the active component targets of A. lancea and CP-related targets were identified, and a protein–protein interaction (PPI) network was constructed and analysed using the STRING database and Cytoscape software to obtain the core targets. GO functional enrichment analysis and KEGG pathway enrichment analysis of the intersecting targets were performed using RStudio software. Finally, AutoDock Tools software was employed to validate the molecular docking between the major active components and the core targets. [Results] A total of 9 active components of A. lancea, 279 component-related targets, 1 160 disease-related targets, and 94 intersecting drug-disease targets were identified. The core genes involved in the treatment of CP by A. lancea mainly included IL6, TNF, STAT3, TP53, and EGFR. The major signalling pathways included the PI3K-Akt signalling pathway, lipid and atherosclerosis, and proteoglycans in cancer. The intervention of A. lancea in CP involves a complex biological process with multiple targets and pathways. [Conclusions] This study elucidates the mechanism of A. lancea against CP from the perspectives of multi-component and multi-target actions, and provides a theoretical basis as well as directions for subsequent molecular biological experiments. |
