Pharmacological effects of acacetin on liver protection, improvement of osteoarthritis, depression, and myocardial ischemia-reperfusion injury
| 刊名 |
Asian Agricultural Research |
| 作者 |
Junhao LI, Jiaru YE, Huizhen PEI, Shuang REN, Linbo JIA, Chenghao JIN |
| 作者单位 |
College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University |
| DOI |
10.19601/j.cnki.issn1943-9903.2026.07.007 |
| 年份 |
2026 |
| 刊期 |
7 |
| 页码 |
45-48 |
| 关键词 |
Acacetin, Liver protection, Osteoarthritis, Depression, Myocardial ischemia-reperfusion injury |
| 摘要 |
This article reviews the latest research progress on acacetin: regarding cardioprotection, it mitigates myocardial ischemia-reperfusion injury and chronic heart failure by modulating the HMGB1/RAGE and GAS6/Axl pathways. In the liver, it alleviates alcoholic liver injury through antioxidant and anti-inflammatory mechanisms. In the nervous system, it improves depression-like behaviors by inhibiting the HIF-1α/NLRP3 pathway. In bones and joints, it ameliorates osteoarthritis by blocking the JAK/STAT pathway. Furthermore, it reduces acute lung injury by inhibiting the NLRP3 inflammasome and improves diabetic vascular endothelial dysfunction via the eNOS/PERK pathway. These findings provide a theoretical basis for the development and utilization of acacetin. |
