| 刊名 | Asian Agricultural Research |
| 作者 | Juan YAO, Xiaochao GANG, Qiaoyan YAN, Yue YU, Ao LI, Bingqian LI |
| 作者单位 | Changchun University of Chinese Medicine |
| DOI | 10.19601/j.cnki.issn1943-9903.2026.04.008 |
| 年份 | 2026 |
| 刊期 | 4 |
| 页码 | 43-46 |
| 关键词 | Brain insulin resistance, Obesity, Neurological disorders |
| 摘要 | This article systematically reviews the molecular mechanisms of brain insulin resistance (BIR) and its role in Alzheimer's disease, Parkinson's disease, depression, anxiety disorders, and ischemic stroke. Research demonstrates that obesity triggers BIR by inducing chronic inflammation and metabolic dysregulation, which subsequently drives neurodegeneration through dysfunction in insulin signaling pathways. Current research still faces limitations such as inconsistent evaluation systems and unclear temporal causality. This review aims to provide a theoretical reference for the early prevention, control, and precision treatment of obesity-related neurological disorders. |
