| 摘要 |
[Objectives] To investigate the evidence-based effect of electroacupuncture on the post stroke inflammatory response and elucidate its potential molecular mechanisms. [Methods] A systematic electronic search of the Medline, PubMed, and Web of Science databases was initially performed up to June 2024. The risk of bias of the included studies was evaluated using RevMan 5.4 software, in accordance with the guidelines set forth in the Cochrane Handbook for Systematic Reviews. The random-effects model or fixed-effects models was employed to estimate the standardized mean difference (SMD). [Results] A total of 15 studies, comprising a total of 182 rats or mice, were included in this review. The pooled analysis of these trials showed a statistically significant reduction in the level of TNF-α (12 studies, SMD=-2.38, [95% CI, -2.86 to -1.90], P<0.000 01, I2=49), and IL-1β (11 studies, SMD=-2.41, [95% CI, -3.32 to -1.50], P<0.000 01,I2=57). Additionally, the compiled data demonstrated a notable and statistically significant elevation in the IL-10 level (6 studies, SMD=1.56, [95% CI, 0.42 to 2.70], P=0.008, I2=68). [Conclusions] The findings of this systematic review and meta-analysis demonstrate that electroacupuncture stimulation has the potential to regulate the inflammatory responses after stroke. |
