| 摘要 |
[Objectives] To study the anti-inflammatory effect of Laggerae Alatae Herba extract and its mechanism. [Methods] Inflammation models of xylene-induced ear edema in mice, acetic acid-induced increased permeability of abdominal capillaries in mice, and carrageenan-induced paw edema in mice were established; xylene-induced ear swelling model in bilateral adrenalectomized mice was established. The levels of MDA, NO and SOD in inflammatory tissues of paw were measured. [Results] Compared with the model group, the high and medium dose groups of Laggerae Alatae Herba extract had significant inhibitory effect on xylene-induced ear edema in mice, except for the low dose group (P>0.05); Laggerae Alatae Herba extract inhibited the increase of celiac capillary permeability induced by acetic acid and paw edema induced by carrageenan in mice. Compared with the model group, in the mice model with bilateral adrenal glands removed, the high and medium dose groups of Laggerae Alatae Herba extract could significantly inhibit the xylene induced ear swelling of the mice. The high and medium dose groups of Laggerae Alatae Herba extract could significantly decrease the levels of MDA and NO, and significantly increase the level of SOD in the paw tissue. [Conclusions] The Laggerae Alatae Herba extracts have anti-inflammatory activity, and the anti-inflammatory effect of the extracts does not depend on the hypothalamic-pituitary-adrenal a |
