| 刊名 | Medicinal Plant |
| 作者 | Shengbin CHEN, Guangyuan XIE, Yulong WEI, Yanqiong HUANG, Xuanyang ZENG, Xiaomin DENG, Mingzheng HUANG |
| 作者单位 | The First Affiliated Hospital of Guangxi University of Chinese Medicine |
| DOI | 10.19601/j.cnki.issn2152-3924.2023.06.007 |
| 年份 | 2023 |
| 刊期 | 6 |
| 页码 | 31-34 |
| 关键词 | Wuwei Xiaoke Granule, Orthogonal test, Preparation technology |
| 摘要 | [Objectives] To optimize the extraction and preparation technology of Wuwei Xiaoke granules. [Methods] Taking the extraction rate of extract as the scoring standard, the water extraction technology was optimized by orthogonal test. The influence of the proportion of pharmaceutical excipients on the molding conditions of Wuwei Xiaoke granules was investigated using granule molding rate, solubility, moisture, granularity, water-soluble extract and microorganism examination as evaluation indicators, and the optimal molding technology was optimized. [Results] The extraction technology was soaking in water for 0.5 h and heat extraction twice for 1 h each time: adding 10 times the amount of water in the first time, and adding 8 times the amount of water in the second time. The best molding technology was: extract density 1.13-1.16 (55-60 ℃), extract: soluble starch=1:2, and 0.15% stevioside. [Conclusions] The water extraction technology and granule molding technology optimized by orthogonal test are reliable and stable, with good granular characteristics, easy oral administration and good solubility, which can maximize the comprehensive quality of Wuwei Xiaoke granules, and provide an effective reference for the preparation and production of Wuwei Xiaoke granules. |
