| 刊名 | Medicinal Plant |
| 作者 | Xin XIE, Liyuan LI, Aipeng LI, Zhidong LEI, Suoyi HUANG |
| 作者单位 | School of Basic Medical Sciences, Youjiang Medical University for Nationalities;School of Pharmacy, Youjiang Medical University for Nationalities; Key Laboratory of Characteristic Ethnic Medicine Research in Youjiang Basin, Youjiang Medical University for Nationalities |
| DOI | 10.19601/j.cnki.issn2152-3924.2023.06.004 |
| 年份 | 2023 |
| 刊期 | 6 |
| 页码 | 19-21,26 |
| 关键词 | Mahoniae Caulis, Tumor cells, Anti-tumor, Activity screening |
| 摘要 | [Objectives] To explore the antitumor activity of the extracts of petroleum ether, ethyl acetate, n-butanol and aqueous solution from Mahoniae Caulis. [Methods] The extracts were extracted with petroleum ether, ethyl acetate, n-butanol and aqueous solution respectively, and then concentrated. The inhibitory effects of these extracts on the growth of three tumor cell lines in vitro were detected by CCK-8 method, and the IC50 value was calculated. [Results] The four extracts inhibited the growth of the three tumor cell lines in vitro, among which the n-butanol extract had the best anti-tumor activity. The IC50 values of the n-butanol extract on human gastric cancer (SGC-7901), human breast cancer (MCF-7) and human liver cancer (BEL-7404) cell lines were 0.23, 0.25 and 0.58 mg/mL, respectively.[Conclusions] The ethanol extract of Mahoniae Caulis under petroleum ether, ethyl acetate, n-butanol and aqueous solution had certain anti-tumor effect, and n-butanol extract had the best anti-tumor activity. |
