| 摘要 |
［Objectives］To explore the clinical effect of Erxian decoction on relieving low back pain after percutaneous vertebroplasty (PVP) of vertebral compression fracture caused by postmenopausal osteoporosis (PMOP). [Methods] Ninety patients who were treated in Suzhou TCM Hospital from September 2021 to January 2023 were randomly divided into three groups: traditional Chinese medicine group (n=30), western medicine group (n=30) and blank group (n=30). The patients in all the three groups were treated with basic anti-osteoporosis drugs. The patients in the traditional Chinese medicine group were treated with Erxian decoction after PVP, and those in the western medicine group were treated with celecoxib to relieve pain after operation. The visual analogue (VAS) score, Oswestry dysfunction index (ODI) score, TCM syndrome score and serum indexes such as interleukin-6 (IL-6) and estrogen E2 were recorded before treatment and 2 weeks, 1 month and 3 months after treatment. [Results] (i) In terms of pain relief, the VAS score of the western medicine group was lower than that of the traditional Chinese medicine group after 2 weeks of treatment, but there was no significant difference in VAS score between the two groups after 1 month and 3 months, and the pain improvement of the two groups was better than that of the blank group. (ii) After 3 months of treatment, the ODI score in the traditional Chinese medicine group was lower than that in the western medicine group, and the improvement of TCM syndrome in the traditional Chinese medicine group was better than that in the other two groups 1 and 3 months after treatment (P<0.05). (iii) The level of IL-6 in the western medicine group was lower than that in the other groups after 2 weeks, and there was no significant difference between the two groups after 3 months of treatment. After 3 months of treatment, the level of E2 in the traditional Chinese medicine group was higher than that before treatment and higher than that in the western medicine group and the blank group, but there was no significant difference between the two groups (P>0.05). [Conclusions] Both Erxian decoction and non-steroidal anti-inflammatory drugs can relieve residual low back pain after PVP, and their long-term effects are similar, but Erxian decoction has more advantages in alleviating pain, muscle and joint pain and sensory abnormalities in postmenopausal women. Moreover, it is safe and reliable, and is worthy of clinical application. |
