| 刊名 | Medicinal Plant |
| 作者 | Chuhui ZHOU， Zhouyan HUANG， Fengxian ZHAO， Yong CHEN， Xianxian LIU， Xiaolian LIANG， Wenli LI |
| 作者单位 | Guangxi University of Chinese Medicine |
| DOI | 10.19601/j.cnki.issn2152-3924.2023.05.010 |
| 年份 | 2023 |
| 刊期 | 5 |
| 页码 | 45-48 |
| 关键词 | Diploclisia glaucescens (B1.) Diels, n-butanol extract, Rats with adjuvant arthritis |
| 摘要 | ［Objectives］ To study the protective effect and mechanism of n-butanol extract of Diploclisia glaucescens (B1.) Diels on rats with adjuvant arthritis. [Methods] A rat adjuvant arthritis (AA) model with similarities to a clinical RA (rheumatoid arthritis) patient was used, and the model was made by injection of Complete Freund’s adjuvant (CFA). Body mass and joint swelling degree were used as indicators, and the organ index was calculated and the synovial tissue of rats was examined under microscope to evaluate the protective effect of n-butanol extract on arthritis. The effects of n-butanol extract on TNF-α, IL-1β and PGE2 contents in rat serum were detected by ELISA kit. [Results] Arthritic rats experienced significant weight loss; the n-butanol extract reduced the joint swelling in rats. It exerted an effect on rat organs and reduced the contents of TNF-α, IL-1β and PGE2 in rat serum, and also reduced synovial inflammation in rats. [Conclusions] The n-butanol extract of D. glaucescens can protect rats with adjuvant arthritis by reducing the content of inflammatory factors. |
