| 摘要 |
[Objectives] To investigate the efficacy and mechanisms of action of the Dangshen Xiangfu Chinese herbal patch through the application of network pharmacology. [Methods] The HIT 2.0 database and the TCMSP database were utilized to identify and gather the active ingredients and corresponding action targets of the Dangshen Xiangfu Chinese herbal patch. Cytoscape software was utilized to create network diagrams and analyze the primary active ingredients and action targets of the herbal patch formulation. Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the identified action targets were conducted using the DAVID database. The SymMap database was utilized to analyze the network information pertaining to traditional Chinese medicine (TCM), syndromes and the associated symptoms of the medicinal plants found in the Chinese herbal patch. [Results] The network pharmacological analysis suggested that the primary Chinese herbal ingredients of the Dangshen Xiangfu Chinese herbal patch may include Radix Glycyrrhizae Preparata, Fructus Aurantii, Cyperi Rhizoma, Radix Codonopsis, etc. The primary active ingredients may include quercetin, luteolin, kaempferol, fisetin, nobiletin, naringenin, isosinensetin, baicalin, etc. These ingredients exhibited a protective effect on the intestinal tract and were advantageous in the regulation of abnormal intestinal function. The primary targets of action included PTGS2, CASP3, HSP90AA1, PTGS1, AKT1, and MMP9. The active ingredients of the Dangshen Xiangfu Chinese herbal patch may exert a regulatory effect on gastrointestinal inflammation by interacting with the pertinent targets within the PI3K-Akt signaling pathway, the IL-17 signaling pathway, and other related pathways in the body. The principal symptoms associated with this condition may include qi stagnation, qi deficiency, and food accumulation. [Conclusions] This study offers a framework for analyzing the efficacy and mechanisms of action of external preparations derived from medicinal plants. |
