A Discussion on the Relationship among Hepatic Stellate Cells, Hepatic Sinusoidal Endothelial Cells and Hepatic Sinusoidal Capillarization in the Development of Hepatic Fibrosis
刊名 Animal Husbandry and Feed Science
作者 Yang Miao1#, Lu Mingzhe1#, Peng Yue2*, Lin Jiang2*, Guo Weiqian1, Liu Xiyu1
作者单位 1.Graduate School, Guangxi University of Chinese Medicine, Nanning 530001, China; 2. School of Basic Medicine, Guangxi University of Chinese Medicine, Nanning 530004, China
DOI 10.19578/j.cnki.ahfs.2023.01-06.002
年份 2023
刊期 1
页码 5-10
关键词 Hepatic stellate cells; Hepatic sinusoidal endothelial cells, Hepatic sinusoidal capillarization; Hepatic fibrosis
摘要 Hepatic stellate cells, hepatic sinusoidal endothelial cells and hepatic sinusoidal capillarization are closely related to the occurrence and progression of hepatic fibrosis. The pathological activation of hepatic stellate cells is the central link of hepatic fibrosis, and hepatic sinusoidal capillarization also promotes the occurrence and development of liver diseases. In the course of hepatic fibrosis, there is always a mutually reinforcing relationship between the activation of hepatic stellate cells and the capillarization of hepatic sinusoids. This paper strives to find an effective way to intervene or even reverse this vicious cycle by deeply investigating the effect of hepatic stellate cells and hepatic sinusoidal capillarization on hepatic fibrosis and their mutual promotion, and provide a new idea for the treatment of hepatic fibrosis, which is of great significance for relieving and reversing hepatic fibrosis.