| 刊名 | Agricultural Biotechnology |
| 作者 | Kun LI;Guanghe ZHU;Danning FU;Lele LI |
| 作者单位 | School of Medicine, Huanghe Science and Technology University, Zhengzhou 450063, China |
| DOI | DOI:10.19759/j.cnki.2164-4993.2024.01.018 |
| 年份 | 2024 |
| 刊期 | 1 |
| 页码 | 74-77 |
| 关键词 | 2-Methyl-3-(methylthio)pyrazine; Growth curve; Minimum inhibitory concentration |
| 摘要 | Previous studies have shown that glycine and proline are pharmacophores that display antibacterial activity. In the present study, glycine and proline were derivated to diketopiperazine compounds by chemical synthesis method, and their antibacterial activities were evaluated by three strains of spoilage bacteria, Escherichia coli, Pseudomonas aeruginosa and Shewanella putrefaciens, and the relationship of their antibacterial activities and structures was also investigated. Uv-vis spectrophotometry was used to determine the growth curves of three kinds of active indicator bacteria. Minimum inhibitory concentration (MIC) was determined by micro broth dilution method. The results showed that 2-methyl-3-(methylthio)pyrazine had significant antibacterial activity against three strains of the bacteria, and its MIC was 1.25%. It indicates 2-methyl-3- (methylthio)pyrazine has the potential to be developed as a kind of preservative in future. |
