| 摘要 |
[Objectives] This study was conducted to promote the rational use of special use level of antibiotics in clinic and delay the emergence of drug resistance. [Methods] The application of antibiotics for special use among inpatients of a hospital in 2019 was analyzed. The data in the drug information management system of the hospital were queried, and the collected expert consultation records of special-use antibiotics were sorted out. Indicators including the use rate of special-use antibiotics, antibiotic use density (AUD), defined daily dose system (DDDs) and defined daily dose system cost (DDDc) of each drug, the annual pathogen detection rate, disease distribution and pathogenic microorganism detection were summarized and analyzed for inpatients in the hospital retrospectively. [Results] In 2019, the average annual use rate of special-use antibiotics in the hospital was 1.53%, and the average annual use density was 1.59 DDDs. The antibiotics with the top three DDDs were imipenem and cilastatin, meropenem and cefepime. The antibiotics with the top three DDDc were voriconazole dispersible tablets, voriconazole for injection, and meropenem for injection. The average annual detection rate of microorganisms was 85.77%. The diseases were mainly diagnosed as respiratory infections such as pneumonia and secondary infections after radiotherapy and chemotherapy before medication, and the detected pathogens were mainly Candida and its subspecies, Escherichia coli, and Klebsiella and its subspecies. [Conclusions] The clinical use of special-use antibiotics in the hospital was basically reasonable, but there were still some problems. It is necessary to increase management efforts, strengthen training for relevant medical personnel, and provide management ideas for further standardizing the use of antibiotics in the hospital. |
