| 摘要 |
Ginkgo biloba is a deciduous tree belonging to Ginkgo, Ginkgoaceae. It is often used to treat dizziness, tinnitus, vertigo, hyperlipidemia and diabetic peripheral neuropathy. Bilobalide is a natural active compound derived from the leaves and fruits of G. biloba, which exhibits a range of pharmacological effects, including anti-inflammatory properties, obesity treatment, neuroprotection, and hepatoprotection. This paper provides a comprehensive review of the pharmacological actions and molecular mechanisms of bilobalide, with a particular focus on its roles in anti-inflammatory responses, metabolic regulation, neuroprotection, and hepatoprotection. Research has demonstrated that bilobalide exerts its pharmacological effects through the regulation of various signaling pathways, including AMPK/SIRT1/mTOR, STAT3, and Nrf-2/HO-1. This paper aims to establish a theoretical foundation for the further investigation, development, and application of bilobalide. |
