| 刊名 | Animal Husbandry and Feed Science |
| 作者 | Xing Qianwen1, Xa Cui2, Zhao Fang2, Cui Shasha2, Wu Liyong2, Zhang Liang3, Li Yandong1*, Han Xue2* |
| 作者单位 | 1.Hebei Provincial Station of Veterinary Drug and Feed, Shijiazhuang 050035, China; 2. College of Food and Biology, Hebei University of Science and Technology, Shijiazhuang 050018, China; 3. Hebei Provincial Animal Husbandry Station, Shijiazhuang 050035, China |
| DOI | 10.19578/j.cnki.ahfs.2025.01-06.007 |
| 年份 | 2025 |
| 刊期 | 1 |
| 页码 | 41-48 |
| 关键词 | High-resolution mass spectrometry; Self-formulated feed; Illegal additions |
| 摘要 | [Objective] The paper aimed to effectively reduce the occurrence of bacterial resistance associated with breeding practices and to mitigate food safety risks by controlling the illegal use of veterinary drugs in self-formulated feed at the source. [Method] A screening database comprising 274 illegally added chemical drugs in self-formulated feed was established utilizing ultra-performance liquid chromatography coupled with quadrupole/electrostatic field orbitrap high-resolution mass spectrometry (HPLC-Q-Exactive Focus/MS). Subsequently, 253 batches of self-formulated feed samples from various farms in Hebei Province were screened and quantitatively analyzed. [Result] The screening results indicated the presence of 8 pharmaceutical components across 10 batches of self-formulated feed samples, with a detection rate of 3.2% and concentrations ranging from 0.06 to 28 851.8 μg/g. [Conclusion] The application of high-resolution mass spectrometry is feasible and highly significant for the risk monitoring of illegally added drugs in self-formulated feed. |
